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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2014,53(23):5796-5799
2014年06月01日
Suffrutines A (1) and B (2), a pair of novel photochemical Z/E isomeric indolizidine alkaloids, with a unique and highly conjugated C-20 skeleton, were isolated from the roots of Flueggea suffruticosa. The structures were elucidated by extensive analysis of NMR spectra and single-crystal X-ray diffraction. The light-induced isomerization and hypothetical biogenetic pathway to 1 and 2, as well as their activity for regulating the morphology of Neuro-2a cells are also discussed.
alkaloid, snatural products, NMR spectroscopy, photochemistry, structure elucidation
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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2023,62(50):
2023年12月03日
A synthetic strategy based on biogenetic building blocks for the collective and divergent biomimetic synthesis of cleistoperlones A-F, a cinnamoylphloroglucinol collection discovered from Cleistocalyx operculatus, has been developed. These syntheses proceeded successfully in only six to seven steps starting from commercially available 1,3,5-benzenetriol and involving oxidative activation of stable biogenetic building blocks as a crucial step. Key features of the syntheses include a unique Michael addition/ketalization/1,6-addition/enol-keto tautomerism cascade reaction for the construction of the dihydropyrano[3,2-d]xanthene tetracyclic core of cleistoperlones A and B, and a rare inverse-electron-demand hetero-Diels-Alder cycloaddition for the establishment of benzopyran ring in cleistoperlones D-F. Moreover, cleistoperlone A exhibited significant antiviral activity against acyclovir-resistant strains of herpes simplex virus type 1 (HSV-1/Blue and HSV-1/153).
Antiviral Activity, Biogenetic Building Blocks, Biomimetic Synthesis, Cinnamoyl Phloroglucinols, Plant Natural Products
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【期刊论文】Crystalline mate for structure elucidation of organic molecules
CHEM,2024,10(3):
2024年05月13日
Single -crystal X-ray diffraction (SCXRD) analysis is the most definitive structure determination method, yet it hinges upon the success of crystal growth and that can sometimes be challenging for volatile or complicated molecules. Here, we report a highly fluorinated cyclic trinuclear Ag(I) pyrazolate complex (Ag 3 Pz 3 ) with strong p -acidity as a crystalline mate for structural elucidation of those having difficulty crystallizing on their own. Dozens of oxygenated organic molecules were smoothly co -crystallized with Ag 3 Pz 3 , regardless of their sizes and shapes. Their chemical structures were unambiguously determined by subsequent SCXRD analysis. Ag 3 Pz 3 is highly adaptive and can pack with organic molecules in four different types of binding modes according to their structural and electronic attributes. Moreover, Ag 3 Pz 3 is a robust crystalline mate and can be directly employed for the co -crystallization of mixtures without tedious separation, as exemplified by the successful identification of individual components in mixtures and even the crude extract of natural medicine.
EFFECTIVE CORE POTENTIALS, NATURAL-PRODUCTS, COMPLEXES, SPONGE
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