Synthesis of a New Chiral Cyclic o-Hydroxynaphthylphosphonodiamide and its Application as Ligand Catalyst in Asymmetric Silylcyanation of Aromatic Aldehydes，成果详细信息-中国科技论文在线

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Synthesis of a New Chiral Cyclic o-Hydroxynaphthylphosphonodiamide and its Application as Ligand Catalyst in Asymmetric Silylcyanation of Aromatic Aldehydes

周正洪， Ke He ， Zhenghong Zhou ， Lixin Wang ， Kangying Li ， Guofeng Zhao ， Qilin Zhou ， Chuchi Tang

SYNLETT 2004, No. 9, pp. 1521-1524，-0001，（）：

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摘要/描述

A new chiral cyclic o-hydroxynaphthylphosphonodiamide (+)-2 was synthesized starting from (+)-cis-1,2,2-trimethylcyclopentane-1,3-diamine. The absolute configuration of phosphorus atom was determined as S by X-ray diffraction analysis. Excellent enantioselectivity (up to 98.3% ee) was achieved in asymmetric silylcyanation of aromatic aldehydes using a chiral titanium complex prepared in situ from Ti(Oi-Pr)4 and (+)-2 as the catalyst.

关键词: chiral phosphonodiamide ， asymmetric silylcyanation ， catalysis ， enantioselectivity ， aromatic aldehyde

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