Superconducting qubits provide a competitive platform for quantum simulation of complex dynamics that lies at the heart of quantum many-body systems, because of the flexibility and scalability afforded by the nature of microfabrication. However, in a multiqubit device, the physical form of couplings between qubits is either an electric (capacitor) or magnetic field (inductor), and the associated quadratic field energy determines that only two-body interaction in the Hamiltonian can be directly realized. Here, we propose and experimentally synthesize a three-body spin-chirality interaction in a superconducting circuit based on Floquet engineering. By periodically modulating the resonant frequencies of the qubits connected with each other via capacitors, we can dynamically turn on and off qubit–qubit couplings and further create chiral flows of the excitations in the three-qubit circular loop. Our result is a step toward engineering dynamical and many-body interactions in multiqubit superconducting devices, which potentially expands the degree of freedom in quantum simulation tasks.