Preparation of copper-doped graphiyne nanocomposites and their application on radiation protection

• 1、School of Radiation Medicine and Protection,Soochow University,Suzhou 215123

Abstract：Graphiyne (GDY), as a novel two-dimensional material, shows great potential in biomedical field due to its unique physicochemical properties, good biocompatibility and excellent electronic structure. Present : To study the efficacy of copper doped graphiyne nanocomposites (Cu/GDY) in the prevention and treatment of radiation enteritis. Methods : Cu/GDY nanocomposites were synthesized using a two-step method; a model of oxidative stress in IEC-6 cells was constructed; and the ability of Cu/GDY to scavenge reactive oxygen species (ROS) and its radioprotective effects were investigated by in vitro and cellular levels. Results: In this paper, Cu/GDY materials with excellent antioxidant properties were successfully prepared, showing excellent reactive oxygen radical scavenging ability at the test tube level; at the cellular level, they were able to scavenge ionizing radiation-induced ROS and alleviate the level of oxidative stress in the cells. Conclusion: The Cu/GDY nanocomposites on the investigated surfaces were able to alleviate ionizing radiation-induced cellular oxidative stress and enhance their cell survival after irradiation, which has potential for clinical application.

Keywords： Graphiyne Copper-doped graphiyne Reactive oxygen species Radiation enteritis