Association between triglyceride-glucose index and C-reactive protein and frailty: A prospective cohort study

• 1、School of Public Health, Suzhou Medical College of Soochow University

Abstract：Objective: This study aims to explore the relationship between the triglyceride-glucose index (TyG) and C-reactive protein (CRP) with frailty and analyze their effects on the resolution and progression of frailty. Methods: Using data from the China Health and Retirement Longitudinal Study (CHARLS), a frailty index (FI) was calculated based on 42 items. Participants without frailty at baseline were categorized into healthy, pre-frailty, and frailty groups. Multivariable logistic regression models were used to assess thelongitudinal associations of baseline TyG index and CRP with frailty status. Subgroup analyses were conducted to explore potential influencing factors. Furthermore, the relationships between TyG index, CRP, and the resolution and progression of frailty were further examined. Results: After multivariable adjustment, both the TyG index and CRP were significantly positively correlated with frailty status. Compared to participants with low levels of TyG index and CRP, those with high levels had a significantly increased risk of frailty. Participants with a high TyG index were less likely to experience frailty resolution, while high CRP levels may promote the progression of frailty. Conclusion: The findings suggest that regulating metabolic and inflammatory markers may help improve frailty status.

Keywords： Epidemiology Frailty Triglyceride-glucose index C-reactive protein Prospective study