Identification of therapeutic targets for tumor stem cells

• 1、Medical College of Soochow University, Suzhou 215123

Abstract：This study develops a novel scoring system aimed at predicting prognostic markers and drug targets for early cancer diagnosis and treatment, with BASP1 as the primary focus of investigation. Leveraging gene expression data and clinical phenotype information from the TCGA database at a pan-cancer scale, an exhaustive bioinformatics analysis of BASP1 was conducted. The findings indicate that BASP1 exhibits high expression levels in various cancers and is linked to unfavorable prognosis in many instances, contributing to tumor progression. However, it exerts an inhibitory effect on tumor advancement in a limited number of cancers, particularly LGG. Subsequent examination of the correlation between BASP1 and key immune indicators as well as functional enrichment analysis revealed its close association with the immunosuppressive tumor microenvironment across most cancers, except for lower grade glioma (LGG) where this relationship is reversed. In conclusion, this study comprehensively scrutinizes the functional mechanisms of BASP1 across all types of cancer, elucidating potential factors influencing either promotion or inhibition of cancer development while offering innovative insights for targeted therapeutic approaches.?????

Keywords： bioinformatics pan cancer BASP1 immune infiltration tumor stemness