Preparation of GDY/Mn3O4 nanocomposites and their therapeutic effects in inflammatory bowel disease

• 1、School of Radiation Medicine and Protection, Soochow University, Suzhou 215123

Abstract：As a novel two-dimensional nanomaterial, graphdiyne (GDY) have been widely investigated in the biomedical field due to their excellent biocompatibility, photothermal effect, and ability to scavenge reactive oxygen species (ROS). Objective: To investigate the therapeutic effects of graphdiyne/manganese trioxide (GDY/Mn3O4) nanocomposites on mice with inflammatory bowel disease. Methods: GDY/Mn3O4 nanocomposites was prepared via a hydrothermal method; a mouse model of inflammatory bowel disease was induced using dextran sulfate sodium; the ability of GDY/Mn3O4 material to scavenge ROS and its therapeutic efficacy on mice with inflammatory bowel disease were studied through cell and animal experiments. Results: In this study, GDY/Mn3O4 nanocomposites with excellent ROS scavenging ability was successfully prepared. In cell experiments, GDY/Mn3O4 effectively scavenged intracellular ROS and reduced cellular oxidative stress levels. In animal experiments, GDY/Mn3O4 significantly alleviated symptoms in inflammatory bowel disease mice, with therapeutic effects superior to the clinical drug 5-aminosalicylic acid. Conclusion: The results of this study indicate that GDY/Mn3O4 can effectively alleviate and treat inflammatory bowel disease, demonstrating promising potential for clinical applications.

Keywords： Biomedical engineering Graphdiyne Manganese trioxide Reactive oxygen species Inflammatory bowel disease