Biomaterial-Progress in synthesis of Polyhydroxyalkanoates esters

• 1、Changchun University of Technology, College of life science and technology, Changchun City 130000
• 2、Changchun University of Technology,College of life science and technology,Changchun City 130000
• 3、Jilin Agricultural University,College of plant protection,Changchun City 130000

Abstract：Polyhydroxyalkanoates ( PHAs ) are a kind of aliphatic polyesters synthesized by microorganisms under the condition of carbon and nitrogen imbalance. Due to their excellent biodegradability, piezoelectricity and biocompatibility, PHAs have attracted wide attention in the medical field as well as a kind of packaging materials that can replace traditional plastics.However, PHAs produced by microbial fermentation are difficult to be widely used because of high synthesis cost and single structure of synthetic polymers.Therefore, reducing the cost of PHAs and developing new PHAs have become current research hotspots. In this paper, aiming at the problems of PHAs synthesis, the research results of PHAs metabolic pathway modification to increase yield are reviewed from the perspective of metabolic engineering.In addition, from the perspective of biosynthesis, combined with the new PHAs work developed by our team in vitro, the current research results of new PHAs synthesis were reviewed. The solutions to the problems in PHAs synthesis were also given, which provided reference for its application and promotion and new product research.

Keywords： Bioengineering；Polyhydroxyalkanoates；PHA synthase；Novel PHA；In vitro synthesis system