Properties of calcium phosphate materials and their applications in bone repair

• 1、Department of Biology and Chemistry, College of Liberal Arts and Sciences, National University of Defense Technology, Changsha 410073

Abstract：With the population aging, the demand of bone graft materials for clinical treatment is increasing. Affected by the inherent influences of autologous bone transplantation, which is the clinical gold standard, there is no ideal treatment for critical bone defects. Since the 1970s, through the unremitting efforts of scientists, we finally may obtain an artificial bone graft performing as well as the existing gold standard in the near future. Based on the great achievements in the research of calcium phosphate bone repair materials in the past 50 years, this review introduces the related properties ofProperties of calcium phosphate materials and their applications in bone repair calcium phosphate materials as promising candidates for the design of artificial bone grafts, and takes the relevant studies of scholars around the world in recent years as references. Therefore, the research status of the application of calcium phosphate in bone repair is presented. Finally, the existing defects of this material are briefly discussed. The aim of this manuscript is to show the significant achievements made since 1970s and point out the hit ideas of CaP materials research as well as give a comprehensive review of CaP materials in the research of bone repairing.

Keywords： Calcium Phosphate critical bone defects bone tissue engineering artificial bone graft bone repair