A Nanoscale Cation Exchange-Based Sensor Array for Fluorescent Pattern Recognition of Metal Ions

• 1、School of Pharmacy Sciences, Chongqing University, Chongqing 401331

Abstract：Nanocrystals, such as fluorescent semiconductor quantum dots (QDs), can undergo rapid and reversible cation exchange reactions with different metal ions in the solution phase, accompanied by different fluorescence signal changes. Based on this, a sensor array was constructed using four QDs with different compositions and fluorescence properties for fluorescence pattern recognition of seven metal ions such as silver, cobalt, copper, mercury, manganese, lead and iron (III). The linear discrimination (LDA) analysis of fluorescence response mode was used to identify and quantitatively analyze single-component and multi-component mixtures of metal ions, and the detection limit could be as low as 20.0 nmol/L. According to the requirements of limited inspection of heavy metals in drugs specified in the Pharmacopoeia of the People\'s Republic of China (2020), the sensor array was further applied to the detection of heavy metal ions in glucose injection samples, and successfully realized the pattern recognition of different metal ions and their mixed components in glucose injection. Finally, the content range of copper, mercury, lead ions in drug samples was determined simply and quickly by comparing the LDA discrimination scoring chart of the relative position of test sample and standard sample. The experimental results showed that this method could be used as a new method to detect heavy metals in drug quality control.

Keywords： Metal ions Quantum dots Cation exchange Sensor array Pattern recognition?????