水光谱组学研究现状及对中药归经理论的特殊影响
首发时间:2020-11-30
摘要:水光谱组学是一门研究水和水系统分子间氢键组成形态的新兴科学,它通过观察近红外光对水的作用所表征特征峰的变化来分析水系统中溶剂与溶质间的作用关系,且具有非侵入性、分析速度快和定性定量等分析特点,应是研究中医经络及中药归经的有用工具。根据前期建立的中医药超分子"气析"理论,中药归经是中药成分客体与人体经络脏腑主体"印迹模板"自主选择性作用的结果,体现出以水为溶剂的体系的主体分子间非共价键作用特性,故水光谱组学可分析以水为溶剂系统人体的经络、腧穴、脏腑与中药分子的相互作用。本文先梳理水光谱组学的历史沿革、研究方法及其应用现状,再结合中药归经的超分子属性和亟待解决的主要问题,旨在阐明水光谱组学可用于测定人体经络脏腑的超分子结构特征,揭示具特殊基团"印迹模板"中药归经微观物质基础。因此,水光谱组学将成为研究中药归经理论有用的有利工具,也是促进中医药现代化的有效方法。
关键词: 水光谱组学 近红外线 水 活性基团 中药归经理论 中医药现代化
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Current Status of Hydrospectromics Research and Its Special Impact on Meridian Tropism Theory for the Chinese Materia Medica
Abstract:Aquaphotomics is an emerging science that studies the forming and its structure of hydrogen bonds among the pure water or water solvent systems. It analyzes the relationship between solvents and solutes in water systems by observing the changes in characteristic peaks interfered effectively by the near-infrared light. It is a useful tool for studying the meridian for traditional Chinese medicine (TCM) and the meridian tropism for Chinese materia medica (CMM). According to the theory of supramolecular "qi chromatography" of TCM established previously, the CMMs meridian tropism theory is regarded the result of the autonomous and selective interaction between the guest molecule of CMM and the host molecule of meridians and viscera in humanbody with "imprinting templates", reflected the non-covalent bond characteristic interaction among the main molecules in water as solvent with solutes, so the aquaphotomics can monitor the process and results of molecular imprinting of meridians, acupoints, viscera by the CMM in the humanbody as water solvent system. This article has summarized the historical evolution of aquaphotomics and its application status, and analyzed the characteristics of its measurement methods, and thereby to combine the supramolecular properties and main problems in meridian tropism theory of the CMM that are urgently needed to clarify and the illustration was given that the aquaphotomics can be used to determine the meridians and collaterals structure in the humanbod y to reveal the characteristics of supramolecular structure with special "imprinting templates" groups as the microscopic material basis of traditional Chinese medicine. Therefore, the aquaphotomics is a useful modern tool for studying the CMM meridian tropiam theory, as an effective method to promote the modernization of the TCM with the characteristics of non-invasiveness, qualitative and quantitative analysis as fast.
Keywords: aquaphotomics near Infrared water the Chinese materia media meridian tropism theory active group;modernization of traditional Chinese medicine
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水光谱组学研究现状及对中药归经理论的特殊影响
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