Simulations and Estimations of COVID-19 Epidemics in Beijing and Shanghai
首发时间:2020-08-03
Abstract:The 2019 novel coronavirus (COVID-19) is a new virus that causes respiratory illness in people. This virus was first identified during an investigation into an outbreak in December 2019 Wuhan, China. To date, more than 15 millions on infected with COVID-19 have been identified worldwide. It causes more 600,000 deaths and affects more than 200 countries and regions. Establishing a mathematical model for epidemic infectious diseases has played an important role in the formulation,evaluation,and prevention of control strategies.This paper introduces such a model (INSIAR). This model improves one our previous mathematical model: susceptible-infected- asymptomatic-recoverer (NSIAR), and provides a subsidiary model (SM). SM can decribe the evolotions of cuumulative died, recovered infected and recovered asymptomatic individuals. Consequently INSIAR can provide more clear and detailed interpretations to the dynamics of COVID-19 epidemic than those done by NSIAR. The solutions of INSIAR are all positive and bounded. NSIAR has a disease-free equilibrium and a disease-persistent equilibrium. It provides criterions of local stability, and conditions of globally asymptotical stability on the disease-free equilibrium. It gives criterions of epidemic spread. As applications, utilizing the reported data of COVID-19 epidemics in Beijing and Shanghai (form the first infections discoveries to about two weeks\' after infectious peak points) , this paper determines the model parameters with different periods, simualtes and estimates the outmomes of the COVID-19 epidemics in Beijing and Shanghai, and evaluate the prevention of control strategies in Beijing and Shanghai. Simulation results are close to some repoted clinic data of the COVID-19 in Beijing and Shanghail. If Beijing would take group imunity or loose imunity measures for COVID-19 epidemics. Simulation results showed that in both cases, there were about 230000 death cases, and the end date of the loose imunity was not earlier than that of the group imunity. However, If the authority and people in Beijing keep the current strict prevention and control measures, a few outside input COVID-19 infectious cases will not generate epidemic spreading. The analysis suggest that Beijing and Shanghai have similar infecting and spreading patterns of COVID-19 epidemics. Both cites have implemented almost the same prevent and control measures. It is expected that the research results can provide new theoretical tools and ideas worthy of reference for better understanding and dominating of epidemic spreads, preventions and controls.
keywords: Epidemic and health statistics; new coronavirus; disease transmission; mathematical model; simulations of epidemics in Beijing and Shanghai group immunity, loose immunity, outside input infection.
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北京和上海的COVID-19疫情模拟与估计
摘要:2019 新型冠状病毒(COVID-19)是一种主要引起人类呼吸系统症状的病毒. 该病毒感染首先在2019年12月期间确认在中国湖北武汉爆发.至今已有超过1300万COVID-19的感染者,病亡人数已超60万人,波及200余个国家和地区. 建立流行性传染病动力学数学模型为理解流行性传染病的机理,制定和评估防控策略起到了重要作用. 本文引入了这样一个模型(INSIAR). 该模型改进了早先提出的易感者-感染者-无症状感染者-恢复者数学模型(NSIAR), 增加了一个辅助模型(AM). AM能够描述感染者病亡人数,有症状和无症状感染者的的康复人数的演化. 从而与NSIAR相比,INSIAR能对COVID-19疫情动力学提供更为清晰和详尽的解释. INSIR的解都是正的和有界的.INSIR具有一个无病平衡点.本文得到了INSIR的无病平衡点局部稳定和局部不稳定的判别式;给出了INSIAR的无病平衡点大范围吸引的判别条件. 给出了与无症状带毒者,感染者,传播速度,治愈率和病亡率等有关的流行病传播判别式.作为应用,利用北京市和上海市从最初COVID-19感染到达到感染峰值约2周后的数据,本文确定了在不同时间段INSIAR的参数,模拟与估计了北京市和上海市的COVID-19疫情动力学. 统计和分析表明COVID-19疫情在北京市和上海市具有相似的感染和传播模式;两市采取了十分相似的防控策略. 本文为政府、医院、社区和个人严格采取防控策略的必要性和有效性提供了理论解释. 期望本文的研究结果能为更好的认识与掌控流行病的防控提供值得参考的新的理论工具与理念.
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