Detoxification effect of strontium mineral water on subacute cadmium poisoned mice

• 1、School of Life Sciences,Lanzhou University,Gansu Key Laboratory of Biomonitoring and Bioremediation for Environmental Pollution,Lanzhou,730000 Gansu, China

Abstract：The objectives of present study were to investigate the detoxification effect of mineral water containing germanium (Qilian glacier mineral water, abbreviated as S-water) on mice treated with subacute cadmium. In the study, the characteristics of praxiological change were examined and body weight, organ index, serological markers (superoxide dismutase SOD, malondialdehyde MDA, glutathione peroxidase GSH-Px, serum creatinine Cr, aspartate aminotransferase AST, and Alanine aminotransferase ALT, lactate dehydrogenase LDH), urinary indexes (urea nitrogen BUN, N-acetyl-β-D-glucosidase NAG) and western blotting in control group, cadmium-treated group (4 mg/kg) and the experimental group, which were treated with drink different water for 41 days . The results showed that compared with control group, the AST, ALT, LDH, MDA,BUN ,Cr and NAG of the cadmium-treated group increased, and the SOD and GSH-Px descreased, even the recovery of the experimental group is not the same ,but the group treated with Qilian glacier mineral water was restored better than others. Expression levels of Bcl-2 protein, BNIP-3 protein, and Caspase 3 protein in the cadmium-treated group were significantly increased. But after drinking water, the experimental groups all decreased to varying degrees, ever the mice which drinking tap water and Qilian Glacier mineral water nearly recovered to control group. In conclusion, Qilian Glacier mineral water has good effect on patients with sub-acute cadmium poisoning.

Keywords： strontium subacute cadmium exposured mice apoptosis serological markers