Application and Research Progress in safety of Gold Nanoparticles

• 1、School of Pharmaceutical Science, Wuhan University, Wuhan 430071

Abstract：Nanogold is synthesized from gold metal salt to nanosized gold particles. It is one of the most stable metal nanoparticles. Gold nanoparticles have excellent physical and chemical properties, large specific surface area, surface plasmon resonance, and stable Au-S bonds with sulfhydryl groups. The application of nanogold has rapidly spread to optical, biomedical, and catalytic areas. In addition, mumerous one-dimensional, two-dimensional and three-dimensional shapes and hollow gold nanoparticles can be synthesized, and the size can be regulated at 1-100 nm, and different shapes and sizes of gold nanoparticles can also be developed as needed which are used in molecular diagnostics, imaging, drug delivery, and photothermal therapy. With the develpoments of scientific and technological innovations and huge economic benefits, the safety of nano-gold materials has increasingly attracted people\'s attention. The safety of nanogold has not reached a consensus yet. Most studies believe that the toxicity of nanogold is related to its dose, size, shape, and whether the surface is modified. The interaction of nanomaterials in vivo may be potentially toxic to organisms. This article will review the most advanced research and the application of nanogold particles and toxicity issues that need to be solved.At the end, the future development of nanomaterials will be discussed.

Keywords： Gold nanoparticles tumor targeting tumor imaging photothermal therapy nano safety