Metabolic reprogramming in cancer

• 1、Department of Dermatology, Xiangya hospital of Central South University
• 2、Cancer research institute of Central South University

Abstract：Despite seminal studies in the 1920s by Warburg showing a characteristic metabolic pattern for tumors, cancer bioenergetics has often been relegated to the backwaters of cancer biology. Recent studies have shown that metabolism in tumor tissue is more complicated than we previously knew. Despite vigorous glycolysis, in fact，the tumor tissue still retains mitochondrial aerobic metabolism. Mitochondria is one of the main sites of the biosynthesis process of tumor cells tumor. Recent stuies revealed that abnormal fatty acid metabolism, amino acid metabolism play key role in tumorigenesis. The metabolic network in tumor cells was reprogrammed which leading to nutrition flux reorganization and re-derection. Metabolism reprogramming in tumor cells facilitates the balance between the needs of energy supply and the synthesis of biological macromolecules. Targeting cell metabolism is not intended to interfere with the tumor cell's energy supply, but affecting the synthesis of metabolic rate, thereby inhibiting proliferation of the tumor. The review focuses on the importance of metabolic reprogramming in tumour development and cancer therapy. We summarize what is currently known about metabolic reprogramming and establish a framework for understanding its contribution to the altered metabolism of cancer cells.

Keywords： metabolic reprogramming biosynthetic pathways anabolic metabolism carcinogenesis