基于LSC特性探讨RAML中医病机特征
首发时间:2013-12-30
摘要:难治与复发性急性白血病难点是白血病细胞对化疗药物的不敏感性,临床缓解率低,死亡率高。追其复发与难治的根源是患者骨髓中存在有白血病干细胞。按照中西医结合理论分析,LSC导致RAML临床特点与中医的"痰瘀"病机理论基本相符,可概括为"痰瘀交织,凝结于骨髓,髓内气机阻滞,血脉不通,骨髓失养,精血无以生化"。采用具有活血化痰功效的复方浙贝颗粒辅助化疗具有"增效"作用,可明显提高RAML临床缓解率,其增效的靶点是在LSC水平发挥效应。
关键词: 难治性急性白血病 白血病干细胞 痰瘀互阻 复方浙贝颗粒
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To discuss RAML TCM pathogenesis based on the LSC characteristics
Abstract:The difficulties of refractory and recurrent acute leukemia are leukemia cell not sensitive to chemotherapy drugs,low clinical remission rate and high mortality rate .The primary cause is leukemia stem cell existing in patients' bone marrow. According to the theory of Chinese and western medicine, the clinical characters of RAML caused by LSC are basically in agreement with phlegm and blood stasis of TCM pathogenesis theory , which can be summed up as" phlegm and blood stasis are intertwined and condensed in the bone marrow. In bone marrow blocked qi movement leads to blood impassability and malnutrition of bone marrow. The source of essence and blood is deficiency. CZBG has the function of activating blood and dissolving phlegm. CZBG combined with chemotherapy has synergistic effect, which can improve RAML clinical remission rate. the targeted-effect is at the level of LSC.
Keywords: Refractory acute leukemia Leukemia stem cell Phlegm and Blood stasis transimpedance Compound Zhe Bei Granule
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