聚乙二醇分子量对Diels-Alder交联的软骨修复水凝胶HA/PEG力学性能的影响

余凤; 曹晓东

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Effect of PEG molecular weight on mechanical properties of Diels-Alder crosslinked HA/PEG hydrogels for cartilage tissue repair

首发时间：2014-05-09

Yu Feng ^{1
2}
Yu Feng(1987-), female, PhD candidate, Fabrication and design of functional hydrogels for cartilage tissue engineering.
Cao Xiaodong ^{1
2}
Cao Xiaodong，Male，Professor，Bone and cartilage tissue engineering scaffold, Biodegradable nano-composite biomaterials design, Electrospinning technique.

1、School of material science and engineering, South China University of Technology, Guangzhou 510641
2、 National engineering research centre for tissue restoration and recomstruction, Guangzhou, 510006

Abstract：The development of biomaterials that possess mechanical properties mimicking those of native articular cartilage tissue remains an important challenge. Recently, a new class of cross-linked hydrogels with significantly improved mechanical properties has been synthesized by Diels-Alder (DA) click chemistry. In this study, a biological hydrogel was synthesized from hyaluronic acid (HA) and poly (ethylene glycol) (PEG) by DA "click" chemistry and the effect of PEG molecular weight on hydrogel mechanical properties were investigated. The PEG 20K formulation had a lowest compressive modulus of 16.08±1.58 kPa and the strain-at-failure was of about 60.6%. However, the PEG 2K gels had a significantly higher modulus of 67.25±5.76 kPa but lower fracture strain of 44.1%. The loss factor of PEG 20K gel was of 0.026±0.017, which was about 10 times lower than that of PEG 2K gel (0.338±0.057). The well-defined networks of both PEG 2K and PEG 20K gels resulted in good load-bearing and shape recovery properties that mimicked the mechanical properties and behaviors of articular cartilage. All the results suggested that the mechanical properties of HA/PEG hydrogels could be altered and controlled by changing of PEG molecular weight. It would be a hoping scaffold for cartialge tissue engineering.

keywords： hydrogel, PEG, cartilage, Diels-Alder, mechanical property

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聚乙二醇分子量对Diels-Alder交联的软骨修复水凝胶HA/PEG力学性能的影响

余凤 ^{1
2}
Yu Feng(1987-), female, PhD candidate, Fabrication and design of functional hydrogels for cartilage tissue engineering.
曹晓东 ^{1
2}
Cao Xiaodong，Male，Professor，Bone and cartilage tissue engineering scaffold, Biodegradable nano-composite biomaterials design, Electrospinning technique.

1、华南理工大学材料科学与工程学院
2、国家人体组织功能重建工程技术研究中心

摘要：通过组织工程支架的设计来重建关节软骨的力学性能仍然是生物材料研究领域的一大挑战。最近的研究发现,Diels-Alder点击化学法制备的水凝胶，其力学性能具显著增强。在本文中,我们利用点击化学法制备了透明质酸(HA)/聚乙二醇(PEG)的复合水凝胶，并研究了PEG分子量的改变对水凝胶力学性能的影响。结果表明，PEG分子量为20k时，水凝胶具有最小的压缩模量16.08±1.58 kPa, 且其断裂形变量为60.6%。而当PEG分子量为2k时,水凝胶的压缩模量明显提高，可以达到67.25±5.76 kPa，但是其断裂形变减少到44.1%。同时，PEG 20K水凝胶的耗损因子为0.026±0.017，比PEG 2K的水凝胶耗损因子(0.338±0.057)要小10倍。PEG 20K 水凝胶的形变回复性能和抗疲劳性能也明显好于PEG 2K水凝胶，甚至可以承受2000次的循环力学加载。水凝胶的溶胀性与其网络结构和孔径大小有关。孔径大的网络吸水溶胀率高。所有实验结果表明，改变PEG分子量可以很好的调控HA/PEG水凝胶的网络孔径大小及力学性能，有望作为一种良好的软骨组织工程支架。

关键词：水凝胶聚乙二醇软骨 Diels-Alder 力学性能

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1. The Specialized Research Fund for the Doctoral Program of Higher Education of China （20110172120002）

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Yu Feng,Cao Xiaodong. Effect of PEG molecular weight on mechanical properties of Diels-Alder crosslinked HA/PEG hydrogels for cartilage tissue repair[EB/OL]. Beijing:Sciencepaper Online[2014-05-09]. https://www.paper.edu.cn/releasepaper/content/201405-133.

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论文编号	201405-133
论文题目	聚乙二醇分子量对Diels-Alder交联的软骨修复水凝胶HA/PEG力学性能的影响
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