聚乙二醇(PEG)改性聚谷氨酸材料的研究进展
首发时间:2010-01-15
摘要:聚谷氨酸是一类新型的生物降解高分子,因其具有对生物体无毒,无副作用,无免疫原性,并且还具有良好的生物相容性而引起广泛关注。但又因其疏水性,溶解性较差导致降解周期及速度难以控制,它的应用具有了一定的局限性,需要对其能性能进行改性。聚乙二醇(PEG)是具有良好生物相容性的高分子聚合物(分子量几百到几万),也是经FDA批准的极少数能作为体内注射药用的合成聚合物之一,将它引入谷氨酸材料可以得到很好的效果。本文就近十几年来采用PEG改性谷氨酸材料的研究进行了总结,并在传统的改性方法上加入新的研究热点——采用点击化学 (click chemistry and click reaction)的方法进行改性谷氨酸材料,得到很好的预期效果。
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Progresses in modification of Poly (L-glutamic acid) with poly (ethylene glycol)
Abstract:Poly (L-glutamic) is considered as a promising biomedical material and has widely application in pharmaceutical and biomedical field because of its low immunogenicity, good biocompatibility and excellent mechanical properties. But owing to biodegradability, biocompatibility, and especially hydrophobic, PGA has been greatly hampered for the clinical applications because of the difficulty in degrading under the human body conditions. In order to reduce the nonspecific uptake of PGA drug conjugates, other polymers, such as Poly (ethylene glycol) (PEG), can be introduced to PGA either in the form of block or graft copolymers. PEG is known to be low toxicity, certain hydrophilicity, excellent biocompatibility and biodegradability and it has been approved by the U. S. Food and Drug Administration for various clinical applications. In this paper, the progresses of block modification and sidechain modification are summarized, and it also introduced a new method hotspot, click chemistry, to modify the glutamic acid material on the traditional method.
Keywords: Poly (L-glutamic) material Poly (ethylene glycol) biodegradable material modification
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聚乙二醇(PEG)改性聚谷氨酸材料的研究进展
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